Inhibitory action of dopamine on cat carotid chemoreceptors.

Stimulation of the carotid chemoreceptors of the dog by dopamine.

The mechanisms by which chemosensitive receptors in the carotid body are activated by the changes in the Po2, Pco,, or pH of arterial blood or by a variety of chemicals are still unknown. Physiological activation may require the release of a transmitter substance, formed or stored in Type I chemoreceptor cells, which then excites contiguous sensory nerve endings. Recently, a number of investiga...

Analysis of inhibitory and excitatory actions of dopamine on chemoreceptor discharges of carotid body of cat in vivo.

Chemoreceptor discharges were recorded from the carotid sinus nerve of the cat in vivo, and their frequency was used as an index of receptor activity. The effects of dopamine on chemoreceptor activity were analyzed in normal and ischemic carotid bodies. Intra-arterial injections of dopamine (DA) induced various patterns of chemoreceptor responses; simple inhibition, inhibition followed by excit...

Hypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D(2) receptors.

Hypoxia-induced dopamine (DA) release from carotid body (CB) glomus cells and activation of postsynaptic D(2) receptors have been proposed to play an important role in the neurotransmission process between the glomus cells and afferent nerve endings. To better resolve the role of D(2) receptors, we examined afferent nerve activity, catecholamine content and release, and ventilation of genetical...

Concomitant effect of dopamine and acetylcholine on carotid body chemosensory response to hypoxia in the cat

Oxygen sensing by the carotid body chemoreceptors.

Carotid bodies are sensory organs that detect changes in arterial blood oxygen, and the ensuing reflexes are critical for maintaining homeostasis during hypoxemia. During the past decade, tremendous progress has been made toward understanding the cellular mechanisms underlying oxygen sensing at the carotid body. The purpose of this minireview is to highlight some recent concepts on sensory tran...